CASK and CaMKII function in Drosophila memory
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چکیده
منابع مشابه
CASK and CaMKII function in Drosophila memory
Calcium (Ca(2+)) and Calmodulin (CaM)-dependent serine/threonine kinase II (CaMKII) plays a central role in synaptic plasticity and memory due to its ability to phosphorylate itself and regulate its own kinase activity. Autophosphorylation at threonine 287 (T287) switches CaMKII to a Ca(2+) independent and constitutively active state replicated by overexpression of a phosphomimetic CaMKII-T287D...
متن کاملCASK and CaMKII function in the mushroom body α′/β′ neurons during Drosophila memory formation
Ca(2+)/CaM serine/threonine kinase II (CaMKII) is a central molecule in mechanisms of synaptic plasticity and memory. A vital feature of CaMKII in plasticity is its ability to switch to a calcium (Ca(2+)) independent constitutively active state after autophosphorylation at threonine 287 (T287). A second pair of sites, T306 T307 in the calmodulin (CaM) binding region once autophosphorylated, pre...
متن کاملActivity-Dependent Gating of CaMKII Autonomous Activity by Drosophila CASK
The ability of CaMKII to act as a molecular switch, becoming Ca(2+) independent after activation and autophosphorylation at T287, is critical for experience-dependent plasticity. Here, we show that the Drosophila homolog of CASK, also known as Camguk, can act as a gain controller on the transition to calcium-independence in vivo. Genetic loss of dCASK significantly increases synapse-specific, a...
متن کاملPre and postsynaptic roles for Drosophila CASK
CASK ('calcium/calmodulin-dependent serine protein kinase'), also known in Drosophila as 'Caki' or 'Camguk/CMG', and in C. elegans as 'Lin-2', is thought to play an important role in cell-cell junction formation and at synapses in particular. To understand the role of CASK in synapse formation and function, we functionally and morphologically analyzed Drosophila embryonic and larval glutamaterg...
متن کاملCASK regulates CaMKII autophosphorylation in neuronal growth, calcium signaling, and learning
Calcium (Ca(2+))/calmodulin (CaM)-dependent kinase II (CaMKII) activity plays a fundamental role in learning and memory. A key feature of CaMKII in memory formation is its ability to be regulated by autophosphorylation, which switches its activity on and off during synaptic plasticity. The synaptic scaffolding protein CASK (calcium (Ca(2+))/calmodulin (CaM) associated serine kinase) is also imp...
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ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2014
ISSN: 1662-453X
DOI: 10.3389/fnins.2014.00178